Journal article
P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission
ARD McLean, D Stanisic, R McGready, K Chotivanich, C Clapham, F Baiwog, M Pimanpanarak, P Siba, I Mueller, CL King, F Nosten, JG Beeson, S Rogerson, JA Simpson, FJI Fowkes
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Introduction: During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear. Methods: Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, as well as total serum IgG. Multivariable linear regression was conducted to assess the association of peripheral P. falciparum infection during pregnancy or placental P. falciparum infection assessed at delivery..
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Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (project grant and training award to Freya J. I. Fowkes; Infrastructure for Research Institutes Support Scheme grant, Senior Research Fellowship and Program Grant to JGB and IM, NHMRC Independent Research Institutes Infrastructure Support to the Burnet Institute and WEHI), Australian Research Council (Future Fellowship to Freya J. I. Fowkes), and Victorian State Government Operational Infrastructure Support grant to the Burnet Institute. Alistair R. D. McLean is supported by an Australian Postgraduate Award. Shoklo Malaria Research Unit is part of the Mahidol Oxford University Tropical Medicine Research Unit supported by the Wellcome Trust of Great Britain. The Christophe and Rodolphe Merieux Foundation supported the study through a prize (2008) to Francois Nosten. No individuals employed or contracted by the funders (other than the named authors) played any role in: study design, data collection and analysis, decision to publish, or preparation of the manuscript.